Search Result

Pathways Recommended:	Stem Cell/Wnt Neuronal Signaling JAK/STAT Signaling

Results for "

WNT/β-catenin signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Wnt (50) β-catenin (44) Antibiotic (4) APC (1) Apoptosis (11) Autophagy (5) Bacterial (3) Bcl-2 Family (1) Carbonic Anhydrase (1) Casein Kinase (2) CDK (5) E1/E2/E3 Enzyme (1) ERK (2) Estrogen Receptor/ERR (1) Glucocorticoid Receptor (2) GSK-3 (7) Histone Acetyltransferase (1) JNK (1) Mitophagy (1) MMP (3) Neuropeptide Y Receptor (1) NF-κB (2) NOD-like Receptor (NLR) (1) Organoid (4) P-glycoprotein (1) p38 MAPK (1) Parasite (2) PARP (2) Phosphodiesterase (PDE) (2) PROTACs (2) Pyroptosis (1) Reactive Oxygen Species (1) Sodium Channel (1) STAT (2) Survivin (1)
By Research Areas:	Cancer (53) Cardiovascular Disease (4) Endocrinology (2) Infection (3) Inflammation/Immunology (9) Metabolic Disease (11) Neurological Disease (9)

By Targets:

Wnt (50)

β-catenin (44)

Antibiotic (4)

APC (1)

Apoptosis (11)

Autophagy (5)

Bacterial (3)

Bcl-2 Family (1)

Carbonic Anhydrase (1)

Casein Kinase (2)

CDK (5)

E1/E2/E3 Enzyme (1)

ERK (2)

Estrogen Receptor/ERR (1)

Glucocorticoid Receptor (2)

GSK-3 (7)

Histone Acetyltransferase (1)

JNK (1)

Mitophagy (1)

MMP (3)

Neuropeptide Y Receptor (1)

NF-κB (2)

NOD-like Receptor (NLR) (1)

Organoid (4)

P-glycoprotein (1)

p38 MAPK (1)

Parasite (2)

PARP (2)

Phosphodiesterase (PDE) (2)

PROTACs (2)

Pyroptosis (1)

Reactive Oxygen Species (1)

Sodium Channel (1)

STAT (2)

Survivin (1)

By Research Areas:

Cancer (53)

Cardiovascular Disease (4)

Endocrinology (2)

Infection (3)

Inflammation/Immunology (9)

Metabolic Disease (11)

Neurological Disease (9)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Targets Recommended: Wnt β-catenin RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin	Cancer
xStAx-VHLL TFA, a PROTAC, sustains *β-catenin* degradation and manifested strong inhibition of Wnt signaling. xStAx-VHLL TFA promotes β-catenin ubiquitination .

HY-115539

Windorphen	Wnt β-catenin Histone Acetyltransferase	Cancer
Windorphen is a *Wnt/β-catenin* signal inhibitor that specifically targets the function of the c-terminal transactivation domain of *β-catenin-1* but not β-catenin-2. Windorphen selectively targets p300, disrupting the association of the mammalian β-catenin with p300 but not CBP .

HY-120697

MSAB 10+ Cited Publications	Wnt β-catenin	Cancer
MSAB is a potent and selective inhibitor of *Wnt/β-catenin* signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells .

HY-121118

Coronaridine 1 Publications Verification	Wnt	Neurological Disease Cancer
Coronaridine, an iboga type alkaloid, inhibits the **wnt signaling** pathway by decreasing β-catenin expression .

HY-115543

β-catenin-IN-37	β-catenin	Cancer
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC₅₀ values of 20 μM and 31 μM, respectively .

HY-160489

PTK7/β-catenin-IN-2	β-catenin	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-P5819

xStAx-VHLL	Wnt APC PROTACs β-catenin	Cancer
xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC ^–/– mice. xStAx-VHLL can be used as a promising anticancer agent .

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical **WNT signaling (β-catenin)** inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-112799

DK419	Wnt β-catenin	Cancer
DK419 is a potent and orally active *Wnt/β-catenin* signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

HY-151520

Wnt/β-catenin agonist 4

Wnt Cancer

Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of Wnt that activates Wnt/β-catenin signal transmission .

Wnt/β-catenin agonist 4	Wnt	Cancer
Wnt/β-catenin agonist 4 (Derivative 83) is an agonist of *Wnt* that activates *Wnt/β-catenin* signal transmission .

HY-163409

CGK012	β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for *Wnt/βcatenin* signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

HY-141873

Wnt/β-catenin agonist 2	β-catenin	Others
Wnt/β-catenin agonist 2 is a potent *Wnt* agonist. Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and can be used in the research of diseases related to the signal transduction . (From patent WO2007078113A1, compound 39)

HY-141543

YW2065	β-catenin	Cancer
YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of *β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of *wnt/β-catenin signaling inhibition and AMPK** activation .

HY-148055

Wnt/β-catenin agonist 3	β-catenin	Cardiovascular Disease
Wnt/β-catenin agonist 3 (compound 98) is a *Wnt/β-catenin* signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis .

HY-148055A

Wnt/β-catenin agonist 3 hydrochloride	β-catenin	Others
Wnt/β-catenin agonist 3 hydrochloride is a *Wnt/β-catenin* signalling pathway agonist. Wnt/β-catenin agonist 3 (compound 98) can be used for the research of osteoporosis .

HY-133180

YW1128	Wnt β-catenin	Metabolic Disease
YW1128 (compound 3a) is a potent *Wnt/β-Catenin* inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism .

HY-18959

CWP232228 4 Publications Verification
CWP232228, a highly potent selective *Wnt/β-catenin* signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical *Wnt* signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of *Wnt* target genes. JW67 also inhibits colorectal cancer cell growth .

HY-114321

Wnt/β-catenin agonist 1

4 Publications Verification

Wnt Cancer

Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC₅₀ of 0.27 μM .

Wnt/β-catenin agonist 1 4 Publications Verification	Wnt	Cancer
Wnt/β-catenin agonist 1 (compound 3f) is a *Wnt/β-catenin* signalling pathway agonist, with an EC₅₀ of 0.27 μM .

HY-138301

Miclxin DS37262926	β-catenin	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant *β-catenin, involving in Wnt* signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-157990

Wnt/β-catenin-IN-1	Wnt β-catenin	Cancer
Wnt/β-catenin-in-1 (compounds 17) is a *Wnt/β-catenin* signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .

HY-155391

hCA/Wnt/β-catenin-IN-1	Carbonic Anhydrase P-glycoprotein Wnt β-catenin	Cancer
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (K_i: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits *Wnt/β-catenin* signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .

HY-P1416

Foxy-5	Wnt	Cancer
Foxy-5, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-10593

IQ 1	Wnt	Others
IQ 1 is a *Wnt/β-catenin/CBP* signalling sustainer. IQ 1 maintains long-term expansion of *Wnt/β-catenin*-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing *β-catenin/CBP*-mediated transcription and preventing conversion to *β-catenin/p300*-mediated transcription. IQ-1 regulates *Wnt* signalling by interacting with PR72/130. IQ 1 can be used in study of ESCs expansion .

HY-12238

IWR-1

25+ Cited Publications

endo-IWR 1; IWR-1-endo
Organoid Wnt Cancer

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

IWR-1 25+ Cited Publications endo-IWR 1; IWR-1-endo	Organoid Wnt	Cancer
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.

HY-P1416A

Foxy-5 TFA 3 Publications Verification	Wnt	Cancer
Foxy-5 TFA, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-137454

Teplinovivint	Wnt β-catenin	Inflammation/Immunology
Teplinovivint is a potent *wnt/β-catenin* signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research .

HY-16910

WIKI4 2 Publications Verification	PARP β-catenin	Cancer
WIKI4 is a potent tankyrase inhibitor with an IC₅₀ of 26 nM for TNKS2. WIKI4 potently inhibits *Wnt/β-catenin* signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on *Wnt/β-catenin* signaling by inhibiting the enzymatic activity of TNKS2 . WIKI4 is cytotoxic to SCLC cells with an IC₅₀ value of 0.02 μM .

HY-111460

15-Oxospiramilactone NC 043	Wnt	Cancer
15-Oxospiramilactone is a diterpene derivative. 15-Oxospiramilactone can inhibit *Wnt/β-catenin* signaling and tumorigenesis of colon cancer cells .

HY-145267

OM-153	PARP Wnt	Cancer
OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based *Wnt/β-catenin* signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM .

HY-P4858

C-Peptide 1 (rat)	GSK-3	Cancer
C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. C-Peptide 1 (rat) can regulate the Wnt/β-catenin signaling pathway. C-Peptide 1 (rat) can be used for the research of cancer .

HY-153214

YW2036

Wnt β-catenin Cancer

YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC₅₀ value of 637 nM. YW2036 can be used in research of cancer .

YW2036	Wnt β-catenin	Cancer
YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC₅₀ value of 637 nM. YW2036 can be used in research of cancer .

HY-N0020

Echinacoside 5+ Cited Publications	Wnt Reactive Oxygen Species	Neurological Disease
Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits **Wnt/β-catenin signaling*. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal* pathways. Antiosteoporotic activity .

HY-N0432

Astragaloside I Astrasieversianin IV; Cyclosieversioside B	Wnt β-catenin	Metabolic Disease
Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the *Wnt/β-catenin* signaling pathway .

HY-108441

CCT031374 hydrobromide	β-catenin	Cancer
CCT 031374 hydrobromid is a potent inhibitor of β-catenin/transcription factor (TCF) complex signaling. CCT031374 inhibits TCF-dependent transcription of genes of Wnt signaling pathway. CCT 031374 has antitumor activity .

HY-N2785

Desmethylicaritin	Wnt	Metabolic Disease
Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .

HY-117233

UU-T02	β-catenin Wnt	Metabolic Disease Cancer
UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction *(β-catenin/Tcf PPI)* with a K_i of 1.36 μM . UU-T02 inhibits canonical *Wnt* signaling and the growth of colorectal cancer cells .

HY-17439

Salinomycin sodium salt 20+ Cited Publications Salinomycin sodium; Sodium salinomycin	Wnt β-catenin Bacterial Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of *Wnt/β-catenin* signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem cells .

HY-15597

Salinomycin 20+ Cited Publications Procoxacin	Bacterial Wnt β-catenin Mitophagy Autophagy Apoptosis Antibiotic Parasite	Cancer
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of *Wnt/β-catenin* signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells .

HY-N0008

Orcinol glucoside	Wnt	Neurological Disease
Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway .

HY-W010995

2,5-Dimethylcelecoxib	Wnt Survivin β-catenin	Cancer
2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the *Wnt/β-catenin* signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin .

HY-18285

Longdaysin	Casein Kinase ERK CDK	Cancer
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC₅₀s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively .

HY-122816

HLY78 5+ Cited Publications	Wnt β-catenin Apoptosis	Cardiovascular Disease Neurological Disease Cancer
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the *Wnt/β-catenin* signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research .

HY-141891

M435-1279	E1/E2/E3 Enzyme	Cancer
M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the *Wnt/β-catenin* signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1 .

HY-108437

exo-IWR-1	Wnt	Infection Cancer
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway .

HY-N2375

L-Quebrachitol	Wnt β-catenin	Metabolic Disease
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and *Wnt/β-catenin* signaling pathway .

HY-119711

NNGH	MMP	Cancer
NNGH is a stromelysin-1 (MMP-3) inhibitor. MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway. Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression .

HY-151463

CDK8-IN-11	CDK β-catenin	Cancer
CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 can be used in the research of colon cancer .

HY-151463A

CDK8-IN-11 hydrochloride	CDK β-catenin	Cancer
CDK8-IN-11 hydrochloride is a potent and selective CDK8 inhibitor with an IC₅₀ value of 46 nM. CDK8-IN-11 hydrochloride inhibits WNT/β-catenin signaling pathway. CDK8-IN-11 hydrochloride can be used in the research of colon cancer .

Cat. No.	Product Name	Target	Research Area

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin	Cancer
xStAx-VHLL TFA, a PROTAC, sustains *β-catenin* degradation and manifested strong inhibition of Wnt signaling. xStAx-VHLL TFA promotes β-catenin ubiquitination .

HY-P1416A

Foxy-5 TFA 3 Publications Verification	Wnt	Cancer
Foxy-5 TFA, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-P4858

C-Peptide 1 (rat)	GSK-3	Cancer
C-Peptide 1 (rat), a peptide, is aβ-catenin/GSK-3β activator. C-Peptide 1 (rat) can regulate the Wnt/β-catenin signaling pathway. C-Peptide 1 (rat) can be used for the research of cancer .

HY-P5819

xStAx-VHLL	Wnt APC PROTACs β-catenin	Cancer
xStAx-VHLL is a PROTAC β-catenin degrader that manifests strong inhibition of Wnt signaling and sustains degradation of β-catenin in cancer cells and the intestinal organoids derived from wild-type and APC ^–/– mice. xStAx-VHLL can be used as a promising anticancer agent .

HY-P1416

Foxy-5	Wnt	Cancer
Foxy-5, a *WNT5A* agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model .

HY-P2272

NLS-StAx-h	Wnt β-catenin	Cancer
NLS-StAx-h is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation of cancer cells .

HY-P2272A

NLS-StAx-h TFA	Wnt β-catenin	Cancer
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide *Wnt* signaling inhibitor with an IC₅₀ of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells .

HY-P1454

Fz7-21 3 Publications Verification Ac-LPSDDLEFWCHVMY-NH2	Wnt	Cancer
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC₅₀ values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .

HY-P1454A

Fz7-21 TFA 3 Publications Verification Ac-LPSDDLEFWCHVMY-NH2 TFA	Wnt	Cancer
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC₅₀ values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .

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